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Experts in Bioinformatics and Systems Biology
Takeshi Kikuchi Neeraj Wadhwa Hui-Hsien Chou Lynn Adler Paltu Kumar Dhal Stein Aerts Kamal Rawal Abhishek Mitra NGAI Sai Ming Robert Sablowski Murodzhon Akhmedov Luciano Cascione Ivo Kwee MARISSA AMBIO Alberto Arribas Carmena Dr. Rajeev K. Tyagi TRUNG DAC NGUYEN Elizabeth A. Connor Gouher Ahmed Ramana Gosukonda View MoreWe are specifically interested in understanding the molecular mechanisms that lead to axon degeneration and the diseases that originate from this degenerative process.We are also interested in deciphering the mechanisms that control enteric nervous system development. This work involves a combination of molecular biology, live cell imaging, primary neuronal culture, stem cell culture, physiology, calcium imaging and biochemistry. We model the human disease conditions in vitro by lentivirus-mediated overexpression of human disease causing mutant genes or by silencing the normal functioning genes in the neuronal stem cells with the long term goal of understanding the mechanisms and find out the ways to treat or slowdown disease progression.
Understanding the molecular and cellular mechanisms that modulate neuronal development and neurodegeneration