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Experts in Biochemistry
MOHAMMED SALMAN KHAN Biswadip Das Ekaterina M. Nestorovich Joel Caton Anil Roy Dubey Saheem Ahmad Sabrina Bhagwan Carole Ayoub Moubareck Dr.(Ms.) Neeloo Singh Sarah J. Ewing Ruchi Seth Kelly A. Grant Tobias Baskin Magdalena Bezanilla Jeffrey Blanchard Steven D. Brewer Samuel H.P. Chan Catherine Day Pamela L. Tuma Mark Banfield View MoreAzra Rabbani Chadegani
Professor
Institute of Biochemistry and Biophysics
Tehran University of Medical Science
Iran
PhD in Biochemistry from University of London, Chester Beatty Reseerch Institute in 1979, Presently working as professor at University of Tehran
The research in this laboratory is organized aroud three major themes involving chromatin structure and function. (i) Interaction of anticancer drugs with chromatin, DNA and chromatin proteins, histones and nonhistone proteins, in solution, normal cell e.g. Bone marrow cells and cancer cells using biochemical and biophysical approaches. (ii) The effect of anticancer drugs on epigenetic, gene expression and apoptosis. (iii) The effect of heavy metals such as lead, nickel and chromium as a potent environmental poisons on normal cells e.g. alveolar macrophages, hepatocytes and bone marrow cells (stem cells). Also the interaction of these metals with DNA, nucleosomes and chromatin proteins (histones and HMG proteins), alteration of chromatin structure and epigenetic effects are investigated.