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Andrew Gow

Associate Professor
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America

Professor Toxicology
Biography

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions. We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism. In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes. We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia. It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Intrest

emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease

List of Publications
Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
Venosa, A, Gow, JG, Hall, L, Malaviya, R, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor. Toxicol. Sci. 2017;157 (1):222-234. doi: 10.1093/toxsci/kfx032. PubMed PMID:28184907
Massa, CB, Groves, AM, Jaggernauth, SU, Laskin, DL, Gow, AJ. Histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with chronic lung inflammation. PLoS Comput. Biol. 2017;13 (8):e1005570. doi: 10.1371/journal.pcbi.1005570. PubMed PMID:28837561
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