Dr. Califano is Professor of Systems Biology, in the departments of Biochemistry and Molecular Biophysics, of Biomedical Informatics, and in the Institute for Cancer Genetics at Columbia University.  He is currently the funding director and chair of the Columbia Initiative for Systems Biology, which includes the Sulzberger Columbia Genome Center and the Center for Computational Biology and Bioinformatics.  He also serves as Associate Director for Bioinformatics in the Herbert Irving Comprehensive Cancer Center.  Dr. Califano serves on numerous editorial and scientific advisory boards, including the Board of Scientific Advisors of the National Cancer Institute.  Dr. Califano received his doctoral degree from the University of Florence in 1985.  Dr. Califano’s lab, which integrates both experimental and computational research, has pioneered a variety of algorithms for the dissection of transcriptional, post-transcriptional, and post-translational regulatory interactions in mammalian cells and for their interrogation to identify master regulators of aberrant transformation and physiological differentiation/maturation events.  The Califano lab has published the first genome-wide regulatory networks for normal and tumor-related human cells, including neoplastic malignancies of lymphoma and glioma subtypes. 

Biochemistry and Molecular Biophysics