Ana Grande Pérez

Professor
Department of Cell Biology, Genetics and Physiology
Universidad de Malaga
Spain

Professor Genetics
Biography

Ana Grande holds a degree and a doctorate (1998) in Biological Sciences from the University of Santiago de Compostela. In November 2004 she joined the UMA with a Ramón y Cajal contract and in January 2010 she obtained a doctoral teaching contract. Since December 2010 she is Professor of Genetics at the Department of Cell Biology, Genetics and Physiology at the University of Málaga (UMA). Her scientific career has been completed with several predoctoral stays from 1995 to 1998 in the Department of Microbiology at the University of Lund (Sweden) under the supervision of Dr. Einar Everitt; And postdoctoral fellows in 1999-2003 at the Molecular Medicine and Gene Therapy Unit of the Department of Medicine, University of Manchester (United Kingdom), under the supervision of Drs. Pedro R. Lowenstein and Esteban Domingo, and in 2003-2005 at the Severo Ochoa Molecular Biology Center with Dr. Esteban Domingo. She has recently held brief stays of 3-5 months at the Institut des Sciences du Vegetal, CNRS (France) with Dr. Bruno Gronenborn and at the Institute of Molecular and Cellular Biology of Plants (UPV-CSIC) with Dr. Santiago Elena.

Research Intrest

The evolution of quasispecies of RNA viruses and single stranded DNA and the mechanisms that introduce genetic variability into the viral genome.

List of Publications
Martín V, Grande-Pérez A, Domingo E. No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus. Virology. 2008 Aug 15;378(1):185-92.
Domingo E, Martin V, Perales C, Grande-Perez A, Garcia-Arriaza J, Arias A. Viruses as quasispecies: biological implications. InQuasispecies: Concept and Implications for Virology 2006 (pp. 51-82). Springer Berlin Heidelberg.
Grande-Pérez A, Lázaro E, Lowenstein P, Domingo E, Manrubia SC. Suppression of viral infectivity through lethal defection. Proceedings of the National Academy of Sciences of the United States of America. 2005 Mar 22;102(12):4448-52.
Grande-Pérez A, Gómez-Mariano G, Lowenstein PR, Domingo E. Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. Journal of virology. 2005 Aug 15;79(16):10451-9.
Grande-Pérez A, Sierra S, Castro MG, Domingo E, Lowenstein PR. Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proceedings of the National Academy of Sciences. 2002 Oct 1;99(20):12938-43.