Amy Grunden

professor
Department of Plant & Microbial Biology
North Carolina State University
United States of America

Professor Plant Sciences
Biography

Courses taught: MB 351 – General Microbiology, MB 714 – Metabolic Regulation.

Research Intrest

My research program is focused on the study of microorganisms called extremophiles, which are capable of thriving in diverse extreme environmental conditions such as high or low temperatures, high salinity, acidic or alkaline environments. The goals of the extremophile research conducted in my laboratory are first to understand the adaptive mechanisms extremophiles use to survive in harsh environmental conditions and second to exploit these adaptations for biotechnological applications. Research projects currently underway involve using selected extremophile enzymes and synthetic biology approaches to (1) decontaminate toxic organophosphorus-based nerve agents found in some pesticides and chemical warfare agents, (2) generate transgenic plants with increased tolerance to harsh environmental conditions for the purpose of developing plants that can survive in marginal environments, and (3) use extremophile genes to optimize fatty acid production in microalgae for biofuel production and (4) develop a synthetic carbon fixation cycle using archaeal and bacterial enzymes to augment the Calvin-Benson cycle in plant systems. Research in my laboratory has been funded by DOD, DOE, NASA, NCBC, NSF, and the USDA.

List of Publications
Schreck S, Killens-Cade R, Grunden AM. (2014) Characterization of a Halophilic Acyl-CoA Thioesterase from Chromohalobacter salexigens for Use in Biofuel Production. Current Biotechnology. 2: 275-283.
Mathews SL, Pawlak JJ, Grunden AM. (2014) Isolation of Paenibacillus glucanolyticus from Pulp Mill Sources with Potential to Deconstruct Pulping Waste. Bioresource Technology. 164: 100–105.
Mathews SL, Pawlak JJ, Grunden AM. (2015) Bacterial biodegradation and bioconversion of industrial lignocellulosic streams. Appl. Microbiol. Technol. DOI 10.1007/s00253-015-6471-y