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Dr. Sajjan Singh Surana Mahua Choudhury Joseph C. Gregorek Mireya correa Cory Abate-Shen Rosanna G. Abellar Abdul Samad Dr. Ahmed MagdyMetwallyAbd Al Hamid Ester Ballana Guix Jianguo (Jeff) Xia Jen Ronholm David Murdoch Peter D Canoll Susan Best Ryan Blaedow Sofia Avnet Lucio Montanaro Lynn K Carta Kurian P. Abraham Dr Gavin Hunter View MoreAlejandro Iván Hernández
Assistant Professor
Department of Pathology
Suny Downstate Medical Center
United States of America
Alejandro Iván Hernández is an Assistant Professor in the department of Pathology at SUNY Downstate Medical Center, United States of America.
The persistence of synaptic plasticity requires gene expression and protein synthesis in both cell body and synaptic terminals. Identifying essential genes and studying their transcriptional and translational regulation are key steps to understanding how synaptic changes become long lasting. In the invertebrate Aplysia Californica the enzyme PARP1, commonly study in oxidative stress and DNA damage, has been shown to be necessary for long-term memory. In addition, it also has been shown to be necessary for the opening chromatin during development in Drosophila. My laboratory is interested in studying the role of PARP in synaptic plasticity and learning and memory, and how alterations of the enzyme PARP contribute to the process of neurodegenerative disorders, such as Alzheimer, and drug addiction.