Associate Professor
Basic Science and Craniofacial Biology
New York University
United States of America
* Gram-negative bacteria involved in periodontal disease. * Bacterial surface proteins involved in adhesion. * Mixed bacterial infections. Our laboratory is developing methods to rapidly identify bacteria in dental plaque that contribute to periodontal disease. We are using DNA probes that specifically identify species, and even subspecies, of the anaerobic, gram-negative rods implicated in this disease without growing the bacteria. We also look at the virulence factors produced by these bacteria and how the bacteria work together to cause more serious episodes of the disease. We have recently begun to look for bacteriophage-encoded lysins of oral bacteria with the expectation that these lysins could be used therapeutically to treat infections of the oral cavity.