Fisher graduated from University of Mississippi with a BA in 1980 and an MD in 1984 and completed his internship, general surgery residency and plastic surgery residency at the University of California, Irvine Based in Beverly Hills, California, he is best known as the plastic surgeon on ABC's Extreme Makeover television series. He was married to Jessica Canseco, and before that, was married to model/TV hostess Brooke Burke

 Fisher has been selected as “one of the top plastic surgeons in the United States for facial cosmetic and breast surgery” in Best Doctors in America, an authoritative listing of the nation’s most prominent physicians in each medical specialty. He has also been listed annually in the Castle Connolly directory of America’s Foremost Surgeons, an honor bestowed on less than 1% of the country’s physicians. His recognition as a top surgeon and his exposure from Extreme Makeover have led to a number of media appearances for Fisher. Fisher also has an appreciation of the value of developing and sustaining well nourished skin, which led him to work on a line of skin care products. In 2006, Fisher partnered with Paul Scott Premo to found CellCeuticals Skin Care, Inc., a company that aims to develop effective and safe skin treatment products based on scientifically controlled studies.