Christine Campo Alewine

Laboratory of Molecular Biology
The Center for Cancer Research
United States of America

Biography

Dr. Alewine received her M.D. and Ph.D. from the University of Maryland School of Medicine. She completed internal medicine residency in the Osler Medical Training Program at Johns Hopkins Hospital followed by clinical fellowship in Medical Oncology at the National Cancer Institute. She joined the Laboratory of Molecular Biology as an Assistant Clinical Investigator through the support of the Clinical Investigator Development program in 2014 and became a tenure-track investigator through the NIH Lasker Scholar program in 2016. 

Research Intrest

1. Identifying effective combination therapies that can enhance the activity of immunotoxins by increasing delivery and efficacy 2. Evaluating efficacy of new immunotoxins against pancreatic cancer models in vivo and in vitro 3. Developing new syngeneic mouse models that allow evaluation of immunotoxin effect in the context of an intact immune system. 4. Examining the biology of mesothelin. Scientific Focus Areas: Clinical Research, Molecular Biology and Biochemistry 

List of Publications
Zhang J, Bera TK, Liu W, Du X, Alewine C, et al (2014) Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice . PLoS One. 9: e10438
Alewine C, Xiang L, Yamori T, Niederfellner G, Bosslet K, et al (2014) Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. Mol Cancer Ther. 13: 2653-2661
Alewine C, Hassan R, Pastan I (2015) Advances in Anticancer Immunotoxin Therapy Oncologist 20: 176-185.