Frans J de Bruijn  started his scientific career at the Cold Spring Harbor Laboratory in New York, USA, where he worked on Bacteriophage Mu and transposable elements in bacteria with the late Dr. Ahmad Bukhari.  He then moved to Harvard University in Cambridge USA to carry out his Ph.D  research  on the regulation of nitrogen fixation and assimilation genes of Klebsiella pneumonia and Sinorhizobium meliloti  with Professor Fred Ausubel Frans J de Bruijn  started his scientific career at the Cold Spring Harbor Laboratory in New York, USA, where he worked on Bacteriophage Mu and transposable elements in bacteria with the late Dr. Ahmad Bukhari.  He then moved to Harvard University in Cambridge USA to carry out his Ph.D  research  on the regulation of nitrogen fixation and assimilation genes of Klebsiella pneumonia and Sinorhizobium meliloti  with Professor Fred Ausubel

He is interested in understanding pathogenicity, latency and reactivation of viruses in their host to produce vaccine. He is also interested in how bacterial cells respond to the environment by altering which protein they synthesize and in how bacteria detect and respond to stressful conditions.