E. John is in the Department of Microbiology in the Perelman School of Medicine at the University of Pennsylvania. A major goal of his laboratory is to understand the mechanisms of T-cell exhaustion and to develop approaches to reinvigorate the immune system in settings where it fails, including chronic infections and cancer. His group is using a variety of approaches, including multiparameter flow cytometry, systems biology, global gene expression profiling and genetically modified mice, to define cellular and transcriptional pathways involved in T-cell exhaustion and normal memory T-cell differentiation. E. John is in the Department of Microbiology in the Perelman School of Medicine at the University of Pennsylvania. A major goal of his laboratory is to understand the mechanisms of T-cell exhaustion and to develop approaches to reinvigorate the immune system in settings where it fails, including chronic infections and cancer. His group is using a variety of approaches, including multiparameter flow cytometry, systems biology, global gene expression profiling and genetically modified mice, to define cellular and transcriptional pathways involved in T-cell exhaustion and normal memory T-cell differentiation.

fermentation