Suzanne Paradis

Associate Professor of Biology
Life Sciences
Brandeis University
United States of America

Academician Neurology
Biography

"Suzanne Paradis presently working as Associate Professor of Biology at Brandeis University. She completed her Ph.D. at Harvard University. Expertise The ultimate goal of my laboratory is to identify the full complement of molecules that are required for directing proper neural circuit formation in the mammalian central nervous system. To this end, we pioneered an unbiased, forward genetic, RNAi-based screen in cultured primary neurons to identify new molecules that regulate neuronal connectivity. We are currently using gene knockdown and gene targeting approaches both in vitro and in vivo to elucidate the molecular mechanisms by which two genes discovered in my screen, Rem2 and Sema4D, regulate synapse and dendrite development. Awards and Honors German-American Kavli Frontiers of Science Symposium participant (2012) Alfred P. Sloan Research Fellow (2009 - 2011) Basil O'Connor Starter Scholar Research Award (2009 - 2011) Smith Family Award for Excellence in Biomedical Research (2008 - 2011) Society for Neuroscience Career Development Award (2007)

Research Intrest

Biology; Neuroscience

List of Publications
Ghiretti AE, Paradis S. Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins. Trends in neurosciences. 2014 Jul 31;37(7):399-407.
Ghiretti AE, Moore AR, Brenner RG, Chen LF, West AE, Lau NC, Van Hooser SD, Paradis S. Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo. Journal of Neuroscience. 2014 Jan 8;34(2):392-407.
Steinmetz CC, Tatavarty V, Sugino K, Shima Y, Joseph A, Lin H, Rutlin M, Lambo M, Hempel CM, Okaty BW, Paradis S. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell reports. 2016 Sep 6;16(10):2711-22.