Since 2003 I have been involved in the transcriptional control of genes involved in tumor growth, by oligonucleotides and small RNAs. This approach has the dual value of providing a tool for studying the regulation of gene expression and later being able to represent a possible therapeutic strategy. Over the last ten years I have focused on the role of long noncoding RNAs in transcription regulation by developing innovative techniques for describing the mechanisms that link the expression of long noncoding RNAs and that of coding genes. Since 2003, I have been studying transcriptional control of oncogenes and oncosuppressor genes by using oligonucleotides and small RNAs

As part of the experimental therapeutics research group, I'm focused on the selective targeting of a crucial oncogene in prostate cancer, c-myc. Our aim is to silence the expression of this oncogene by antigene oligonucleotides in a stable and specific manner. In addition, we are also interested in a better characterization of their mechanisms of action, in order to improve their potential of gene expression inhibition.