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Paul Garrity

Professor of Biology
Life Sciences
Brandeis University
United States of America

Academician Neurology
Biography

We study the molecular basis of sensory transduction and behavior by investigating the molecular detectors and neural circuits that sense temperature and chemicals. We study thermal and chemical sensation because it allows us to address fundamental questions in neuroscience, molecular biology, biophysics, and evolution, while providing insights relevant to human health and the development of new technologies for controlling neuronal activity. A major focus of the lab is on the molecules and neurons regulating thermal and chemical sensation in flies, emphasizing the ion channels involved in sensory transduction. These studies inform a second area of the lab, the development of "thermogenetic" tools for remote-control activation of neurons using temperature. Finally, we are investigating how thermal and chemical detectors have evolved and naturally vary in animals from insects to vertebrates.

Research Intrest

Neuroscience, Molecular Biology, Biophysics, and Evolution

List of Publications
Greppi C, Budelli G, Garrity PA. Thermotaxis: Some like it hot, but not too hot. eLife. 2015 Dec 15;4:e12838.
Ni L, Klein M, Svec KV, Budelli G, Chang EC, Ferrer AJ, Benton R, Samuel AD, Garrity PA. The ionotropic receptors IR21a and IR25a mediate cool sensing in Drosophila. Elife. 2016 Apr 29;5:e13254.
Knecht ZA, Silbering AF, Ni L, Klein M, Budelli G, Bell R, Abuin L, Ferrer AJ, Samuel AD, Benton R, Garrity PA. Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila. Elife. 2016 Sep 22;5:e17879.
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