Mikael Engskog

Lecturer
Medicinal Chemistry, Organic Pharmaceutical Chemistry
Uppsala Biomedical Centre
Sweden

Biography

I have a magisterexam (Biomolecular Chemistry, University collage of Södertörn) with a clear focus on organic chemistry and bioanalytical chemistry. The exam also cover the fields of pharmacology, biochemistry and physical chemistry. My Ph D. was conducted at Karolinska Institutet, at the unit for analytical carbohydrate chemistry (Prof. Elke Schweda). The thesis deals with the structural characterization of lipopolysaccharides (Haemophilus influenzae) by methods such as masspectrometry, chromatography and NMR. The projects were done in collaboration with a group at Oxford University (Molecular Infectious Diseases Group and Department of Paediatrics). This experience has given me a wide understanding for the field of analytical chemistry when dealing with both practical labwork (sample preparations/purifications (with special focus on carbohydrates) and method development.

Research Intrest

Medicinal Chemistry

List of Publications
Genes required for the synthesis of heptose-containing oligosaccharide outer core extensions in Haemophilus influenzae lipopolysaccharide. Hood DW, Deadman ME, Engskog MK, Vitiazeva V, Makepeace K, Schweda EK, Moxon R. Microbiology. 2010 Nov;156(Pt 11):3421-31. Epub 2010 Aug 5.
Lex2B, a phase-variable glycosyltransferase, adds either a glucose or a galactose to Haemophilus influenzae lipopolysaccharide. Deadman ME, Hermant P, Engskog M, Makepeace K, Moxon ER, Schweda EK, Hood DW. Infect Immun. 2009 Jun;77(6):2376-84. Epub 2009 Mar 16.
A dual role for the lex2 locus: identification of galactosyltransferase activity in non-typeable Haemophilus influenzae strains 1124 and 2019. Engskog MK, Yildirim HH, Li J, Richards JC, Deadman M, Hood DW, Schweda EK. Carbohydr Res. 2009 Mar 31;344(5):632-41. Epub 2009 Jan 17.

Global Scientific Words in Pharmaceutical Sciences