Temperature-related effects of adenosine triphosphate-activated microglia on pro-inflammatory factors.
Tomohiro Matsui, Yukari Motoki, +5 authors Junzo NojimaNeurocritical care2012
BACKGROUND Therapeutic hypothermia protects neurons after severe brain injury. Activated microglia produce several neurotoxic factors, such as pro-inflammatory cytokines and nitric oxide (NO), during neuron destruction. Hence, suppression of microglial release of these factors is thought to contribute partly to the neuroprotective effects of hypothermia.… (More)
Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia.
Xiao-Ying Hua, Camilla I Svensson, Tomohiro Matsui, Bethany Fitzsimmons, Tony L Yaksh, Michael WebbThe European journal of neuroscience2005
Activation of p38 mitogen-activated protein kinase (p38) in spinal microglia is implicated in spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective inhibition of microglial activation, a function that is distinct from its antibiotic activity. In the present study we examined antinociceptive effects of intrathecal (IT)… (More)