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Linda  S.  Gutierrez

Associate Professor
Department of Biology
Wilkes University
United States of America

Academician Bioinformatics and Systems Biology
Biography

Dr. Gutierrez is investigating the role of thrombospondin 1 (TSP-1) in the development of these diseases and testing specific sequences of this protein as a novel and safe therapy for IBD and colorectal cancer. Thrombospondin 1 (TSP-1) is a powerful antiangiogenic with diverse roles in physiological and pathological events. This 450Kd glycoprotein interacts with members of different pathways regulating cell migration, proliferation and apoptosis.

Research Intrest

 Inflammatory bowel disease, colorectal, breast and prostate cancers, angiogenesis, apoptosis

List of Publications
Zak S, Treven J, Nash N, Gutierrez LS. Lack of thrombospondin-1 increases angiogenesis in a model of chronic inflammatory bowel disease. International journal of colorectal disease. 2008 Mar 1;23(3):297-304.
Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008 Mar 1;75(1):9.
Lopez-Dee Z, Pidcock K, Gutierrez LS. Thrombospondin-1: multiple paths to inflammation. Mediators of inflammation. 2011 Jul 3;2011.
Lopez-Dee ZP, Chittur SV, Patel B, Stanton R, Wakeley M, Lippert B, Menaker A, Eiche B, Terry R, Gutierrez LS. Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: transcript profile and therapeutic effects. PLoS One. 2012 Apr 3;7(4):e34590.

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