John K. Crane

Professor of Medicine; Adjunct Professor of Micro
Department of Medicine
Buffalo VA Medical Center
United States of America

Academician Infectious Diseases
Biography

John K. Crane care for patients who are hospitalized at Erie County Medical Center where he also serve as the hospital epidemiologist addressing infection control. He teach medical students, residents, and fellows in both hospital and classroom settings. In UB’s schools of medicine and dentistry, he teach a variety of topics including microbiology, pharmacology and toxicology, oral biology, and gastrointestinal systems, host defenses, and global health. Education and Training: Fellowship, Infectious Diseases, University of Virginia (1990); Residency, Medicine, University of Rochester, Strong Memorial Hospital (1987); MD, MD, University of Virginia (1984); PhD, Pharmacology, University of Virginia (1983). Associate Professor, Medicine, University at Buffalo (1994-present). He is a Co-Medical Director, with Dr. Ryosuke Osawa, of the Erie County TB Clinic. He is interested in international medicine and global health and participate in an annual medical mission trip to Honduras, a trip in which student volunteers are encouraged to participate. He is conduct laboratory research on diarrhea-producing strains of E. coli bacteria. My lab focuses on enteropathogenic Escherichia coli (EPEC), Shiga-toxigenic E. coli (STEC, aka EHEC) and enterotoxigenic E. coli (ETEC). Recently he have discovered that zinc can inhibit the development of resistance to antibiotics in Escherichia coli and other bacteria.

Research Intrest

Infectious Disease; Microbial Pathogenesis; Vitamins and Trace Nutrient

List of Publications
Crane JK, Broome JE, Lis A. Biological Activities of Uric Acid in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli. Infection and immunity. 2016 Apr 1;84(4):976-88.
Wright TE, Boyle KK, Duquin TR, Crane JK. Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype. Infectious diseases. 2016;9:39.
Bunnell BE, Escobar JF, Bair KL, Sutton MD, Crane JK. Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli. PloS one. 2017 May 22;12(5):e0178303.