Jessy J. Alexander 

Research Professor
Department of Medicine
Buffalo VA Medical Center
United States of America

Academician Nephrology
Biography

Jessy J. Alexander research is aimed at understanding the roles of the innate and adaptive immune systems in health and disease. The organs of my interest are the two specialized filtration units, glomeruli and blood-brain barrier, of the kidney and brain respectively. My studies focus on the role of an important arm of the innate immune system, the complement cascade in inflammatory conditions such as glomerulonephritis and lupus. For both disease conditions, the perfect therapy remains an enigma. Once molecular targets are identified, therapeutic strategies will be defined. I teach in UB’s Discovery Seminar Program, which is geared for first- and second-year undergraduates. Education: PhD, Biochemistry, University of Hyderabad (1990) and MS, Science with Zoology, Osmania University (1982). She got many awards and she has nearly 50 publications. I also mentor students through the CLIMB-PRO program. One of my recent students conducted research that resulted in a publication in the journal Kidney International.

Research Intrest

Experimental renal inflammation, Neuropsychiatric lupus, Pathobiology of the complement system

List of Publications
Alexander JJ, Chaves LD, Chang A, Jacob A, Ritchie M, Quigg RJ. CD11b is protective in complement-mediated immune complex glomerulonephritis. Kidney international. 2015 May 31;87(5):930-9.
Alexander J, Jacob A, Quigg RJ. Effects of conventional immunosuppressive therapy on functional and pathological features of CNS lupus in NZB/W mice. F1000Research. 2015 Jun 23;4.
Alexander JJ, Chaves LD, Chang A, Dighe S, Jacob A, Quigg RJ. Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. Cellular and Molecular Immunology. 2016 Sep;13(5):651.