"Dr. Hall is Professor of Medicine at Harvard Medical School, Associate Physician in Medicine at the Massachusetts General Hospital, Associate Chief of the Reproductive Endocrine Unit and a recent President of the Endocrine Society. Dr. Hall’s studies have provided increasing evidence that in women, in addition to the effects of ovarian aging, there are dramatic hypothalamic and pituitary changes, which occur with aging in women and may contribute She is currently investigating the impact of aging on cognitive responses to estrogen replacement using a combination of neuroimaging techniques. In collaborative studies she is also using neuroimaging studies to understand the relationship between hot flashes, sleep and depression in postmenopausal women and women using estrogen deprivation therapy. Dr. Hall has a longstanding interest in patients with idiopathic hypogonadotropic hypogonadism. She was intimately involved in studies leading to FDA approval of pulsatile GnRH for treatment of relative or complete GnRH deficiency. Conception rates are high in patients with hypogonadotropic hypogonadism, while the risks of multiple gestation and hyperstimulation are lower than with alternative therapies. The importance of controlling the risk of multiple gestation is emphasized in studies in which she has demonstrated the profound economic and social impacts of this complication of ovulation induction. Collaborations with others in the MGH Reproductive Endocrine Unit have resulted in dramatic progress in understanding the genetic underpinnings of this disorder that involve not only signals governing the migration of GnRH neurons to the hypothalamus, but also upstream regulation of GnRH in the hypothalamus ."

Hypogonadism, Estrogen deprivation therapy