Gareth Fraser

Lecturer
Animal and Plant Sciences
University of Sheffield
United Kingdom

Academician Plant Sciences
Biography

BSc (Hons) at the University of Portsmouth (2000) MRes at the University of Glasgow (2001) PhD at King´s College London (2005) Post-Doctoral Research Fellow at the Georgia Institute of Technology (2005-2009) Lecturer at the University of Sheffield (2009–present)

Research Intrest

Our research comprises three major areas of interest: (i) biodiversity and morphological evolution of fishes; (ii) comparative dental development and regeneration; and (iii) evolutionary developmental biology. We study the development of dental diversity across a range of vertebrates. Our laboratory questions how varieties of teeth are patterned and modified across species, how they form and how they are replaced for continued production, specifically in fishes. Fishes account for more than half of all extant vertebrates and they have an immense diversity of dental form. The models that we study vary from initial dental patterning and tooth number, to the capacity for dental regeneration with a diverse array of tooth replacement modes. This comparative context provides a framework in which to understand the complexities of dental diversity at the genetic level. Our broad research focus is the genetic basis of developmental mechanisms that regulate vertebrate craniofacial patterning and evolution. By coupling evolutionary and developmental genetic disciplines with more translational biosciences, we aim to break down the complexities of morphological development, diversity and regeneration of the craniofacial skeleton, and in particular the dentition.

List of Publications
Gallego V, Yoshida M, Kurokawa D, Asturiano JF, Fraser GJ. Embryonic development of the grass pufferfish (Takifugu niphobles): From egg to larvae. Theriogenology. 2017 Mar 1;90:191-6.
Cooper RL, Martin KJ, Rasch LJ, Fraser GJ. Developing an ancient epithelial appendage: FGF signalling regulates early tail denticle formation in sharks. EvoDevo. 2017 May 2;8(1):8.
Thiery AP, Shono T, Kurokawa D, Britz R, Johanson Z, Fraser GJ. Spatially restricted dental regeneration drives pufferfish beak development. Proceedings of the National Academy of Sciences. 2017 May 30;114(22):E4425-34.
Seppala M, Fraser GJ, Birjandi AA, Xavier GM, Cobourne MT. Sonic Hedgehog Signaling and Development of the Dentition. Journal of Developmental Biology. 2017 May 31;5(2):6.