Edward Plow

Department Chair
Molecular Cardiology
Cleveland Clinic Lerner Research Institute
United States of America

Academician Cardiology
Biography

Integrins are a large and broadly distributed family of adhesion receptors. Each member is a noncovalent heterodimer composed of an alpha and a beta subunit.

Research Intrest

In addition to its central role in fibrinolysis, plasmin(ogen) is also involved in cell migration, a function that depends on plasminogen receptors on the surfaces of cells.

List of Publications
Sossey-Alaoui K, Pluskota E, Davuluri G, Bialkowska K, Das M, Szpak D, Lindner DJ, Downs-Kelly E, Thompson CL, Plow EF. Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis. FASEB J. 2014 May;28(5):2260-71.
Das R, Ganapathy S, Settle M, Plow EF. Plasminogen promotes macrophage phagocytosis in mice. Blood. 2014 Jul 31;124(5):679-88.