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Dr Simon Lambden

NIHR Clinical Lecturer
Intensive Care Medicine
Cambridge University
United Kingdom

Academician Medical Sciences
Biography

Simon completed his undergraduate training at Guy’s, King’s and St Thomas’ School of Medicine, and began his training in anaesthesia and intensive care in south London, before undertaking an Academic Clinical Fellowship in the north central London School of Anaesthesia. He completed his PhD at Imperial College, London during which he explored the role of regulators of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine, in sepsis. Simon joined the University of Cambridge in 2016 to undertake an NIHR Academic Clinical Lecturer post to complete his clinical training and develop his research programme.

Research Intrest

Nitric Oxide, Nitric Oxide Synthase, Sepsis, Endothelium, Inflammation.

List of Publications
Lambden S, Kelly P, Ahmetaj-Shala B, Wang Z, Lee B, Nandi M, Torondel B, Delahaye M, Dowsett L, Piper S, Tomlinson J. Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, thrombosis, and vascular biology. 2015 Jan 1:ATVBAHA-115.
Kirkman MA, Lambden S, Smith M. Challenges in the anesthetic and intensive care management of acute ischemic stroke. Journal of neurosurgical anesthesiology. 2016 Jul 1;28(3):214-32.
Lambden S, Martin D, Vanezis K, Lee B, Tomlinson J, Piper S, Boruc O, Mythen M, Leiper J. Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia. Nitric Oxide. 2016 Aug 31;58:59-66.

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