Programme Lead: Biomedical and Biological Sciences
Biological and Medical Sciences
Oxford Brookes University
United Kingdom
Membership of professional bodies American Society of Virology Microbiology Society Institute of Biomedical Science (Fellow) Royal Society of Medicine (Associate) Post-doctoral research scientist (1995-2001) - Centre for Ecology and Hydrology (formerly the Institute of Virology & Environmental Microbiology), Oxford. Research Scientist (1991-1995) - Wellcome Research Laboratories, Langley Court, Beckenham Clinical Research Scientist (1990-1991) - Centre for Applied Microbiology and Research, Porton Down, Salisbury
My research interests include the biology of baculoviruses and their application as protein expression tools. These insect-specific viruses are harmless to humans but readily support the expression of significant amounts of proteins in laboratory cultures and in their natural caterpillar hosts. The virus has been developed for this application primarily as a result of two very strong promoters, regulating the viral polyhedrin and p10 genes, but whilst the role of the polyhedrin protein is well established, that of the p10 protein remains obscure. Knock-out and recombinant viruses are beginning to allow us to evaluate biological characteristics, and formulate possible funtions for this non-essential protein.