Dr. Brian C. Ring

Associate Professor
Biology
Valdosta State University
Georgia

Academician Genetics
Biography

Dr. Dr. Brian C. Ring is currently working as a Professor in the Department of Biology, Certified Forensic Biologist Technician, DNA & Serology, Florida Department of Law Enforcement, Adjunct Professor, Florida A&M University, Post-Doctoral Associate, Maize Cytogenetics, Florida State University , Georgia. His research interests includes molecular genetic techniques, genetic or environmental mechanisms and developmental genetics. He is serving as an editorial member and reviewer of several international reputed journals. Dr. Dr. Brian C. Ring is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to molecular genetic techniques, genetic or environmental mechanisms and developmental genetics.

Research Intrest

Research in my lab involves molecular genetic techniques toward understanding how the vertebrate gonad develops. Primary sex determination in most vertebrates results in the development of a single gonad, ovary or testis, from a bipotential primordium, whose developmental fate is controlled by genetic or environmental mechanisms or a combination of both. For example, sex type is determined by sex chromosomes (genetics) in mammals (i.e. XY male in humans) or temperature in alligators (environmental). Regardless of mechanism, the predominant result is the formation of dimorphic individuals, either male or female, which have a testis or ovary, respectively. The mangrove killifish, Kryptolebias marmoratus (Kmar) differs from the predominant mode of dimorphic sex determination. Kmar are synchronous self-fertilizing hermaphrodites whose unique form of reproduction involves a mixed gonad structure referred to as an ovotestis (testis and ovaries form in the same place). The ovotestis is capable of normal gametogenesis and fertilization within a common lumen. Most Kmar are configured this way and can easily be self-crossed through several generations to genetic isogeny where they form “clonal lineages” Kmar males are rare, but easily distinguishable from hermaphrodites.  Too date, a pure Kmar female has not been observed in nature or in the laboratory. Kmar fish are analogous to the invertebrate nematode, C. elegans, a hermaphrodite and a well established model organism in developmental genetics. However, sex determination in C. elegans is genetic, but is unknown in Kmar- although temperature does play a role. Both of these model organisms are advantageous for genetic work because the researcher does not have to inbreed males to females to create homozygosity 

List of Publications
Debbie M. Figueroa, James D. Davis, Cornelia Strobel, Maria S. Conejo, Katherine D. Beckham, Brian C. Ring, & Hank W. Bass. The Selection and Use of Sorghum (Sorghum propinquum) Bacterial Artificial Chromosomes as Cytogenetic FISH Probes for Maize (Zea mays L.) J Biomed Biotechnol. 2011; 2011:386862.
Chiu H, Ring BC, Sorrentino RP, Kalamarz M, Garza D, Govind S.dUbc9 negatively regulates the Toll-NF-kappaB pathways in larval hematopoiesis and drosomycin activation in Drosophila. Dev Biol. 2005, 288(1):60-72.