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Dr Allan Gamble

Senior Lecturer
Pharmacy
Otago University
New Zealand

Academician Pharmaceutical Sciences
Biography

Position Senior Lecturer Qualifications PhD Research summary Medicinal chemistry; design and synthesis of biologically active molecules

Research Intrest

My primary research interests are the design and synthesis of biologically active molecules for the treatment of chronic and infectious disease. I have experience in a range of disciplines including organic and medicinal chemistry, molecular biology and chemical biology. Current research is focused on new technologies for targeted drug delivery and medicinal chemist

List of Publications
Gamble, A. B., & Keller, P. A. (2010). Synthesis of reaction-ready 6,6′-biindole and 6,6′-biisatin via palladium(II)-catalysed intramolecular C–H functionalisation. Chemical Communications, 46(23), 4076-4078. doi: 10.1039/C002098B
Morris, K. M., Cao, F., Onagi, H., Altamore, T. M., Gamble, A. B., & Easton, C. J. (2012). Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Bioorganic & Medicinal Chemistry Letters, 22, 7015-7018. doi: 10.1016/j.bmcl.2012.10.004
Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012
Matikonda, S. S., Orsi, D. L., Staudacher, V., Jenkins, I. A., Fiedler, F., Chen, J., & Gamble, A. B. (2015). Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition. Chemical Science, 6, 1212-1218. doi: 10.1039/c4sc02574a

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