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Dr. Aaron M. Beedle

Vice-Chair and Associate Professor
Department of Pharmaceutical Sciences
Binghamton University
United States of America

Academician Pharmaceutical Sciences
Biography

Dr. Aaron Beedle received her PhD in Neuroscience in 2003 under the mentorship of Dr. Gerald Zamponi at the University of Calgary. Her studies involved cloning, expression, and functional characterization of voltage-gated calcium channels with important relevance to the modulation of these channels in pain pathways. Her technical repertoire for these studies included molecular biology, electrophysiology, pharmacology, biochemistry, and cell imaging.

Research Intrest

Muscular dystrophy: disease pathogenesis and therapeutics Dystroglycan, glycosylation, and the dystrophin-glycoprotein complex Skeletal muscle, heart, and brain function Mouse genetic models

List of Publications
Jarvis SE, Magga JM, Beedle AM, Braun JE, Zamponi GW. G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and Gβγ. Journal of Biological Chemistry. 2000 Mar 3;275(9):6388-94.
Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nature neuroscience. 2007 Jun;10(6):691.
Altier C, Khosravani H, Evans RM, Hameed S, Peloquin JB, Vartian BA, Chen L, Beedle AM, Ferguson SS, Mezghrani A, Dubel SJ. ORL1 receptor–mediated internalization of N-type calcium channels. Nature neuroscience. 2006 Jan 1;9(1):31-40.

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