Dr Charalambos Michaeloudes is a Research Associate at the Airway Disease Section of the National Heart and Lung Institute. His research interests involve the investigation of molecular mechanisms leading to the development of cellular oxidative stress in asthma and chronic obstructive pulmonary disease (COPD), and the role of reactive oxygen species in abnormal airway smooth muscle cell function in these diseases. Dr Michaeloudes studied Medical Biochemistry as an undergraduate at King’s College London. Following the completion of his studies in 2003 he worked for one year as a research technician at King’s College London, School of Health and Life Sciences, working on the development of immunoassays for toxicological analysis. In 2004 he undertook an MSc course in Molecular Life Sciences Research at King’s College London from which he graduated with Distinction. He obtained his PhD in Clinical Medicine Research from Imperial College London in 2009 and since then works as a Research Associate at the National Heart and Lung Institute. Dr Michaeloudes’s research work focuses on the study of molecular mechanisms regulating the balance between reactive oxygen species and antioxidant levels in airway smooth muscle cells. He is particularly interested in the role of the transforming growth factor (TGF)-β pathway, epigenetic effectors and mitochondrial dysfunction in the disruption of this balance and consequently the development of oxidative stress. This work aims to identify novel therapeutic targets for reducing oxidative stress in chronic inflammatory lung diseases and particularly COPD. In parallel to this work, Dr Michaeloudes is involved in projects investigating the signalling pathways behind corticosteroid insensitivity in airway smooth muscle cells from patients with severe asthma and the role of circulating fibrocytes in airway remodelling in asthma.

pulmonary diseases, respiratory disorders