Carrie Breton

Associate Professor
Preventive medicine
California Southern University
United States of America

Academician Medical Sciences
Biography

The overarching goals of my research program are to understand how environmental exposures early in life contribute to the increased risk of disease later in life, as well as the role genetic and epigenetic mechanisms play in driving observed associations. Despite evidence from animal models supporting a developmental origins of adult disease hypothesis (DOHad), which proposes that adverse events during early life program an increased risk for numerous adult diseases, human studies of in utero or childhood environmental exposures have not been a primary focus until recently. My work in evaluating prenatal air pollution and prenatal tobacco smoke exposures provides evidence that early life exposures are important risk factors for cardio-respiratory health in children and young adults.

Research Intrest

Environmental health

List of Publications
Breton CV, Yao J, Millstein J, Gao L, Siegmund KD, Mack W, Whitfield-Maxwell L, Lurmann F, Hodis H. Prenatal air pollution exposures, DNA methyl transferase genotypes, and associations with newborn LINE1 and Alu methylation and childhood blood pressure and carotid intima-media thickness in the Children’s Health Study. Environmental health perspectives. 2016 Dec;124(12):1905.
Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C, Ballereau S, Bellander T, Bousquet J, Bustamante M, Charles MA. Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure. Environmental health perspectives. 2017 Jan;125(1):104.
Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P. Small-magnitude effect sizes in epigenetic end points are important in children’s environmental health studies: the Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group. Environmental health perspectives. 2017 Apr;125(4):511.

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