Dr. Alyssa Johnson is currently working as a Postdoctoral fellow in the Department of Department of Biological Sciences, Louisiana State University , USA. Her research interests includes genetic and molecular causes of age-related degenerative diseases,CRISPR gene editing techniques, disease-causing mutations,degenerative phenotypes in the whole organism. she is serving as an editorial member and reviewer of several international reputed journals. Dr. Alyssa Johnson is the member of many international affiliations. She has successfully completed his Administrative responsibilities. she has authored of many research articles/books related to genetic and molecular causes of age-related degenerative diseases,CRISPR gene editing techniques, disease-causing mutations,degenerative phenotypes in the whole organism..

My lab is exploring links between the genetic and molecular causes of age-related degenerative diseases, such as ALS, Alzheimer’s and Parkinson’s disease. A common hallmark of almost all degenerative diseases is the progressive accumulation of protein aggregates. Autophagy-lysosome mediated degradation is the major pathway that clears aggregates from the cytoplasm and autophagy defects are associated with many degenerative diseases. Using CRISPR gene editing techniques, we are introducing disease-causing mutations into the endogenous fruit fly genome and using a combination of genetic, biochemical and microscopy methods to study how the autophagy-lysosome pathway is affected in various cell types (e.g. neurons, glia and muscles) and how these molecular defects drive progressive degenerative phenotypes in the whole organism.