Alessandra Giorgetti

Research Associate
Medicine
Centro de Medicina Regenerativa de Barcelona
Spain

Academician Molecular Biology
Biography

Alessandra Giorgetti holds a Bachelor in Biology (1998) and PhD in Molecular Medicine from the University of Milan, Italy. She pursued postdoctoral training at the GMP facility, Ospedale Maggiore Policlinico Milano and in Dr. Rafii’s group at Weill Cornell Medical College in New York from 2004 to 2008, where she acquired a invaluable expertise in human hematopoietic stem cells, with a particular interest on cord blood stem cells (CBSCs). Then she joined the CMR[B] as a Research Associate at the Stem Cell Bank from 2008 to 2011. In 2012 she started her period in Inbiomed as head of the Laboratory of Hematopoiesis and Blood Disorders. The main interest of her lab was the development of new approaches to generate in vitro hematopoietic blood cells, for cell replacement therapies. She continued this work at Josep Carreras Leukaemia Research Institute where she has been working for almost three years. During her stay there she increased her expertise and contributed to developing new strategies for the in vitro generation of blood cells from human iPSCs. In 2016 she moved to CMR[B] as a Ramón y Cajal researcher and her long-term goal is to identify developmental pathways that are involved in blood stem cells (hematopoietic stem cells, HSCs) specification during early stage of human embryo development, to direct the differentiation of human induced pluripotent stem cells (iPSCs) into clinically relevant blood stem cells.

Research Intrest

The main interest of her lab is the development of new approaches to generate in vitro hematopoietic blood cells, for cell replacement therapies

List of Publications
Bruzos-Cidon C, Castaño J, Torrecilla M, Sanchez-Pernaute R, Giorgetti A. (2016) Fast and efficient neural conversion of human hematopoietic cells. Curr. Protoc. Stem Cell Biol. 39:1F.15.1- 1F.15.20.
Navarro S, Giorgetti A, Raya A, Tolar J. (2017) Induced Pluripotency and Gene Editing in Fanconi anemia. Curr Gene Ther Jan 18 [Epub ahead of print].
Romero-Moya D, Santos-Ocaña C, Castaño J, Garrabou G, Rodríguez-Gómez JA, Ruiz-Bonilla V, Bueno C, González-Rodríguez P, Giorgetti A, Perdiguero E, Prieto C, Moren-Nuñez C, Fernández-Ayala DJ, Cascajo MV, Velasco I, Canals JM, Montero R, Yubero D, Jou C, López-Barneo J, Cardellach F, Muñoz-Cánoves P, Artuch R, Navas P, Menendez P. (2017) Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency. Stem Cells. May 4 [Epub ahead of print].