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Experts in Biomedical Sciences
Jon P Mochel Zhao Zhidong Mark Ehrensberger Limin Chen Jason R. Wiles Anirban Dutta Fakhri Al-Bagdadi Hermann Bragulla Jun Xia Levent Dirikolu Yun Wu Albert H. Titus Debanjan Sarkar Joseph Francis Hitesh Anantray Vyas Charles Lee Martha Littlefield Ciprian N. Ionita J. Michael Mathis Lei L. Ying View MoreAileen Boshoff
Senior Lecturer
Biotechnology
Rhodes University
South Africa
The research is focused on the study of molecular chaperones from parasitic systems. Our group has been isolating and characterising molecular chaperones from Trypanosoma brucei, the causative agent of human and animal African trypanosomiasis as well as from Plasmodium falciparum, the causative agent of malaria. Molecular chaperones play a wide range of roles in the cell and they are required to assist both parasites as they move from a cold blooded insect vector to a warm blooded mammalian host. They also play an important role during differentiation of the parasites during different stages of development. Certain molecular chaperone proteins have been identified as essential to the survival of both parasites. The aim is to design small molecule inhibitors to this class of important proteins.
Molecular chaperones